Positive regulation of nuclear division

Across TCGA patient cohorts, RNA activity of the Positive regulation of nuclear division pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ANLN_S485, TPX2_S486, and TPX2_S738, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of nuclear division activity versus ANLN_S485 in BRCA (Pearson r = 0.43).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ANLN_S485 →	+0.939	+0.030	.002	.001	3	6
LUAD	TPX2_S486 →	+1.135	+0.048	<.001	<.001	3	6
BRCA	TPX2_S738 →	+0.746	+0.030	<.001	<.001	3	6
BRCA	DDX21 →	+0.436	+0.024	.001	<.001	3	5
LUAD	ERCC6L_S1028 →	+0.904	+0.057	<.001	<.001	3	5
LSCC	HSP90AB1 →	+0.277	+0.039	.003	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051785 vs ANLN_S485 — BRCA

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