Positive regulation of nuclear division

Across TCGA patient cohorts, RNA activity of the Positive regulation of nuclear division pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NUP160, CDCA7, and PDLIM1P4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of nuclear division activity versus NUP160 in LSCC (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	NUP160 →	+0.425	+0.511	.001	.002	3	6
GBM	CDCA7 →	+1.039	+0.681	<.001	.002	3	5
HNSC	PDLIM1P4 →	-0.459	-0.830	<.001	<.001	3	5
GBM	EZH2 →	+0.654	+0.832	.006	<.001	3	5
GBM	FBXO5 →	+0.768	+0.749	<.001	<.001	3	5
GBM	SGO1 →	+0.818	+1.010	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051785 vs NUP160 — LSCC

Explore this scatter interactively →