Positive regulation of nuclear division

Across TCGA cell cohorts, RNA activity of the Positive regulation of nuclear division pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF432, TMEM150A, and FHL2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF432 grouped by Positive regulation of nuclear division-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	ZNF432 →	+0.514	+0.198	.002	.002	3	5
BONE	TMEM150A →	-0.852	-0.290	.004	.007	3	5
LUNG_NSCLC_LUAD	FHL2 →	+1.567	+0.215	<.001	<.001	3	4
URINARY_TRACT	ZNF133 →	+0.471	+0.238	.009	<.001	3	4
OESOPHAGUS	RAB3B →	+2.035	+0.321	.005	.003	3	4
KIDNEY	MIS18BP1 →	+1.015	+0.322	.009	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF432 by Positive regulation of nuclear division activity — LIVER

Explore this box plot interactively →