Positive regulation of nuclear division

Across TCGA cell cohorts, RNA activity of the Positive regulation of nuclear division pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are APLP1, KIAA1549, and ZNF45, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, APLP1 grouped by Positive regulation of nuclear division-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	APLP1 →	-0.376	-0.223	.001	.004	3	3
BLOOD_Lymphoma	KIAA1549 →	+0.276	+0.177	<.001	.004	3	3
BLOOD_Lymphoma	ZNF45 →	-0.416	-0.223	.001	.004	3	3
LIVER	KDM6B →	-0.213	-0.357	.004	.009	3	3
LIVER	NSDHL →	-0.256	-0.636	.002	.003	3	3
SKIN	MSL3P1 →	-0.206	-0.306	.003	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

APLP1 by Positive regulation of nuclear division activity — BLOOD_Lymphoma

Explore this box plot interactively →