Regulation of nuclear division

Across TCGA patient cohorts, RNA activity of the Regulation of nuclear division pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GINS1, PLK1, and KIF11, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of nuclear division activity versus GINS1 in HNSC (Pearson r = 0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	GINS1 →	+1.204	+1.415	<.001	.007	3	8
BRCA	PLK1 →	+1.802	+1.213	<.001	<.001	3	7
BRCA	KIF11 →	+1.439	+1.024	<.001	.001	3	6
OV	CDC20 →	+0.923	+0.766	<.001	<.001	3	6
BRCA	CENPF →	+1.673	+0.830	<.001	<.001	3	6
BRCA	HJURP →	+1.207	+0.791	.002	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051783 vs GINS1 — HNSC

Explore this scatter interactively →