Negative regulation of cell division

Across TCGA cell cohorts, RNA activity of the Negative regulation of cell division pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GRAP2, TRAPPC1, and TWIST2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GRAP2 grouped by Negative regulation of cell division-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	GRAP2 →	-0.167	-0.384	.003	.003	3	3
BLOOD_Lymphoma	TRAPPC1 →	-0.737	-0.383	.004	.003	3	3
BLOOD_Lymphoma	TWIST2 →	-0.076	-0.337	.005	.008	3	3
PANCREAS	SRR →	-1.464	-0.353	<.001	<.001	3	3
BONE	LOXL3 →	-2.776	-0.258	.008	.001	3	3
BONE	R3HDM2 →	+1.641	+0.342	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GRAP2 by Negative regulation of cell division activity — BLOOD_Lymphoma

Explore this box plot interactively →