Negative regulation of cell division

Across TCGA cell cohorts, RNA activity of the Negative regulation of cell division pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BLM, BCAR1, and E2F8, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cell division activity versus BLM in LUNG_NSCLC_LUSC (Pearson r = 0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	BLM →	+0.841	+0.096	.001	.001	3	9
BLOOD_Leukemia	BCAR1 →	-1.250	-0.106	<.001	<.001	3	7
BONE	E2F8 →	+1.365	+0.181	<.001	<.001	3	7
CNS	SHFL →	-1.150	-0.082	<.001	<.001	3	7
BONE	MVP →	-2.726	-0.121	.001	<.001	3	7
URINARY_TRACT	RAD51 →	+1.046	+0.111	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051782 vs BLM — LUNG_NSCLC_LUSC

Explore this scatter interactively →