Negative regulation of cell division

Across TCGA cell cohorts, RNA activity of the Negative regulation of cell division pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C1orf116, NOB1, and TANGO6, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cell division activity versus C1orf116 in STOMACH (Pearson r = -0.74).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	C1orf116 →	-3.766	-1.531	<.001	.001	3	9
PANCREAS	NOB1 →	+0.937	+1.535	<.001	<.001	3	8
PANCREAS	TANGO6 →	+1.222	+1.183	<.001	.001	3	7
OESOPHAGUS	HARS1 →	+0.679	+1.179	.006	.008	3	7
BREAST	PARK7 →	+0.771	+1.131	<.001	<.001	3	7
OVARY	DDX19A →	+0.593	+0.754	.009	.003	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051782 vs C1orf116 — STOMACH

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