Response to redox state

Across TCGA patient cohorts, RNA activity of the Response to redox state pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SLC5A6, CBR1, and SPR, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to redox state activity versus SLC5A6 in HNSC (Pearson r = 0.09).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SLC5A6 →	+0.365	+0.052	.006	.004	3	5
HNSC	CBR1 →	+0.600	+0.052	<.001	.001	3	4
HNSC	SPR →	+0.297	+0.055	.004	.005	3	4
PDAC	CDK17_S137 →	-0.223	-0.040	<.001	.002	3	4
PDAC	CPM →	-0.444	-0.039	<.001	<.001	3	4
HNSC	HSD17B8 →	+0.380	+0.057	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051775 vs SLC5A6 — HNSC

Explore this scatter interactively →