Response to redox state

Across TCGA patient cohorts, RNA activity of the Response to redox state pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SMPD3, TSPAN8, and KDELR2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to redox state activity versus SMPD3 in PDAC (Pearson r = 0.11).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	SMPD3 →	+0.789	+0.780	.001	<.001	3	4
OV	TSPAN8 →	+1.334	+0.208	.003	.006	3	4
PDAC	KDELR2 →	+0.212	+0.533	.008	.004	3	4
PDAC	PGAP4 →	+0.507	+0.917	.004	<.001	2	5
BRCA	MAPK10 →	+0.395	+0.452	.001	.005	3	4
LUAD	CHST3 →	-1.015	-0.569	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051775 vs SMPD3 — PDAC

Explore this scatter interactively →