Response to redox state

Across TCGA cell cohorts, RNA activity of the Response to redox state pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNF7, ADH5, and SLC7A11, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RNF7 grouped by Response to redox state-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RNF7 →	-0.305	-1.666	<.001	<.001	3	9
OVARY	ADH5 →	-0.197	-1.192	.008	.007	2	7
KIDNEY	SLC7A11 →	-0.312	-1.178	.007	.004	3	6
STOMACH	HIVEP3 →	-0.220	-1.198	.003	.001	3	5
PANCREAS	TANK →	-0.317	-1.134	<.001	.001	3	5
LUNG_NSCLC_LUSC	HIF1AN →	-0.103	-1.527	.008	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RNF7 by Response to redox state activity — LARGE_INTESTINE

Explore this box plot interactively →