Response to redox state

Across TCGA cell cohorts, RNA activity of the Response to redox state pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C1QL1, UBL7, and ALDH16A1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, C1QL1 grouped by Response to redox state-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	C1QL1 →	-2.174	-1.175	.005	.001	3	4
BLOOD_Leukemia	UBL7 →	+0.538	+0.995	.002	.002	3	3
BLOOD_Leukemia	ALDH16A1 →	+1.137	+1.362	.006	<.001	3	3
SKIN	TSC2 →	-0.500	-0.955	.005	.006	3	3
SKIN	UBASH3B →	-1.011	-1.006	<.001	.003	3	3
LUNG_NSCLC_LUSC	EBI3 →	-0.943	-1.082	.004	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

C1QL1 by Response to redox state activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →