Response to redox state

Across TCGA cell cohorts, RNA activity of the Response to redox state pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GRSF1, PLP2, and DCK, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to redox state activity versus GRSF1 in KIDNEY (Pearson r = 0.81).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	GRSF1 →	+1.079	+1.612	.006	<.001	3	6
BLOOD_Lymphoma	PLP2 →	-2.093	-1.276	<.001	<.001	3	5
BLOOD_Lymphoma	DCK →	+1.622	+0.920	.001	.003	3	5
BLOOD_Leukemia	YEATS2 →	+0.605	+0.186	<.001	<.001	2	6
UPPER_AERODIGESTIVE_TRACT	PTK2 →	+1.008	+1.961	.001	<.001	3	5
BLOOD_Leukemia	WDR33 →	+0.507	+0.189	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051775 vs GRSF1 — KIDNEY

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