Actin crosslink formation

Across TCGA patient cohorts, RNA activity of the Actin crosslink formation pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPARC, COL10A1, and SULF1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Actin crosslink formation activity versus SPARC in OV (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SPARC →	+1.527	+0.440	<.001	<.001	3	8
OV	COL10A1 →	+2.118	+0.418	<.001	<.001	3	8
OV	SULF1 →	+2.027	+0.750	<.001	<.001	3	8
OV	NTM →	+1.581	+0.436	<.001	<.001	3	8
OV	COL11A1 →	+3.001	+0.438	<.001	<.001	3	8
OV	ADAMTS12 →	+1.982	+0.802	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051764 vs SPARC — OV

Explore this scatter interactively →