Actin crosslink formation

Across TCGA cell cohorts, RNA activity of the Actin crosslink formation pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDKN2A, MARCKS, and EFHD2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Actin crosslink formation activity versus CDKN2A in BONE (Pearson r = 0.70).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	CDKN2A →	+4.478	+0.462	.003	.001	3	5
LARGE_INTESTINE	MARCKS →	+1.237	+0.308	.001	.002	3	5
BONE	EFHD2 →	+1.516	+0.597	.004	.003	2	6
BLOOD_Lymphoma	KCNJ11 →	-1.113	-0.254	.008	.001	3	4
URINARY_TRACT	FAHD2B →	-1.484	-0.396	.005	.008	3	4
LUNG_SCLC	PSIP1 →	+1.318	+0.306	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051764 vs CDKN2A — BONE

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