Protein de-ADP-ribosylation

Across TCGA patient cohorts, RNA activity of the Protein de-ADP-ribosylation pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLCL2, NMUR1, and CHDH, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein de-ADP-ribosylation activity versus PLCL2 in LSCC (Pearson r = 0.22).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PLCL2 →	+0.430	+0.126	.006	.004	3	6
BRCA	NMUR1 →	+0.310	+0.094	<.001	<.001	3	5
BRCA	CHDH →	+0.926	+0.119	.001	.004	3	4
GBM	RPL12P30 →	+0.798	+0.103	.004	.001	3	4
BRCA	ERFL →	+0.361	+0.111	.005	.009	3	4
GBM	TSPOAP1 →	+0.861	+0.118	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051725 vs PLCL2 — LSCC

Explore this scatter interactively →