Protein de-ADP-ribosylation

Across TCGA cell cohorts, RNA activity of the Protein de-ADP-ribosylation pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CSPG5, MPHOSPH10, and SECISBP2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CSPG5 grouped by Protein de-ADP-ribosylation-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	CSPG5 →	-1.084	-0.697	.004	.004	3	3
BLOOD_Leukemia	MPHOSPH10 →	+0.786	+1.333	<.001	<.001	3	3
LUNG_NSCLC_LUSC	SECISBP2 →	+0.892	+0.645	<.001	.003	3	3
CNS	ZDHHC4 →	-0.614	-0.620	.001	.004	3	3
CNS	WDR33 →	+0.455	+0.970	<.001	.001	2	4
SOFT_TISSUE	SCRT1 →	+0.052	+1.284	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CSPG5 by Protein de-ADP-ribosylation activity — OVARY

Explore this box plot interactively →