Protein de-ADP-ribosylation

Across TCGA cell cohorts, RNA activity of the Protein de-ADP-ribosylation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF726, EEF1G, and CD48, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein de-ADP-ribosylation activity versus ZNF726 in BLOOD_Leukemia (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ZNF726 →	+1.751	+0.917	.004	.004	3	6
BONE	EEF1G →	+0.705	+1.458	<.001	<.001	3	5
KIDNEY	CD48 →	+0.273	+1.670	.005	<.001	3	4
SKIN	LYL1 →	+1.824	+1.504	.001	.003	3	4
CNS	ARF5 →	-1.412	-1.719	.002	<.001	3	4
STOMACH	DNAJB11 →	-0.944	-1.487	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051725 vs ZNF726 — BLOOD_Leukemia

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