Biological process involved in interaction with symbiont

Across TCGA patient cohorts, RNA activity of the Biological process involved in interaction with symbiont pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are P4HA2, SNX6, and PLXDC2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Biological process involved in interaction with symbiont activity versus P4HA2 in LSCC (Pearson r = 0.13).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	P4HA2 →	+0.545	+0.030	<.001	.002	3	6
COAD	SNX6 →	+0.208	+0.023	<.001	.005	3	6
BRCA	PLXDC2 →	+0.572	+0.024	<.001	<.001	3	6
UCEC	ANKRD44 →	+0.248	+0.051	.007	.003	3	5
GBM	LCP1 →	+0.701	+0.032	.001	.003	3	5
BRCA	TIMP2 →	+0.543	+0.019	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051702 vs P4HA2 — LSCC

Explore this scatter interactively →