Biological process involved in interaction with symbiont

Across TCGA cell cohorts, RNA activity of the Biological process involved in interaction with symbiont pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FN1, COL6A2, and COL8A1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Biological process involved in interaction with symbiont activity versus FN1 in KIDNEY (Pearson r = 0.70).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	FN1 →	+4.959	+0.276	.006	.001	3	7
CNS	COL6A2 →	+2.007	+0.140	.002	.001	3	5
SKIN	COL8A1 →	+2.805	+0.163	.008	.004	3	4
SOFT_TISSUE	NBEAL2 →	-1.750	-0.228	.004	.002	3	4
SOFT_TISSUE	HNRNPF →	-0.695	-0.200	.001	<.001	3	4
BLOOD_Leukemia	SLA2 →	-2.427	-0.150	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051702 vs FN1 — KIDNEY

Explore this scatter interactively →