Biological process involved in interaction with host

Across TCGA patient cohorts, RNA activity of the Biological process involved in interaction with host pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FOXO1, COL1A2, and CEACAM3, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Biological process involved in interaction with host activity versus FOXO1 in COAD (Pearson r = 0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	FOXO1 →	+0.750	+0.196	<.001	.001	3	2
OV	COL1A2 →	+1.981	+0.125	.002	.004	3	2
COAD	CEACAM3 →	+0.444	+0.176	.005	<.001	3	2
COAD	CRTC3-AS1 →	-0.255	-0.195	.008	.003	3	2
COAD	KLHDC7B-DT →	+0.353	+0.147	.004	<.001	3	2
BRCA	SLC2A3 →	+0.786	+0.232	.003	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051701 vs FOXO1 — COAD

Explore this scatter interactively →