Biological process involved in interaction with host

Across TCGA cell cohorts, RNA activity of the Biological process involved in interaction with host pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IL1RAP, RAPGEF2, and ANKRD1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Biological process involved in interaction with host activity versus IL1RAP in STOMACH (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	IL1RAP →	+2.596	+0.275	<.001	.005	2	7
CNS	RAPGEF2 →	+0.879	+0.213	<.001	<.001	3	6
LUNG_NSCLC_LUAD	ANKRD1 →	+2.795	+0.128	<.001	<.001	3	6
BONE	FLAD1 →	-1.282	-0.475	.008	<.001	3	5
BONE	NKX3-1 →	+2.348	+0.379	.004	.003	3	5
BONE	PARVA →	+2.332	+0.395	.005	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051701 vs IL1RAP — STOMACH

Explore this scatter interactively →