Protein delipidation

Across TCGA patient cohorts, RNA activity of the Protein delipidation pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SIRT6, ESYT2, and STAP2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein delipidation activity versus SIRT6 in HNSC (Pearson r = 0.12).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SIRT6 →	+0.228	+0.095	.006	<.001	3	6
UCEC	ESYT2 →	-0.244	-0.077	.004	.003	3	5
LSCC	STAP2 →	+0.630	+0.037	<.001	<.001	3	5
UCEC	MFN2 →	-0.146	-0.100	.004	<.001	3	4
LUAD	SIRT6_T294 →	+0.336	+0.054	<.001	<.001	3	4
LUAD	STX4 →	+0.181	+0.035	.004	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051697 vs SIRT6 — HNSC

Explore this scatter interactively →