Protein delipidation

Across TCGA patient cohorts, RNA activity of the Protein delipidation pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MRPL57P3, RN7SL351P, and PUS10, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein delipidation activity versus MRPL57P3 in CCRCC (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	MRPL57P3 →	+0.389	+0.449	<.001	.003	3	3
LSCC	RN7SL351P →	+0.378	+0.644	<.001	<.001	3	3
GBM	PUS10 →	+0.429	+0.726	<.001	.002	3	3
GBM	TRIP4 →	+0.274	+0.654	.004	<.001	3	3
GBM	MB →	-0.334	-0.749	.003	<.001	3	3
GBM	ABCA11P →	+0.381	+0.564	.004	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051697 vs MRPL57P3 — CCRCC

Explore this scatter interactively →