Protein delipidation

Across TCGA patient cohorts, RNA activity of the Protein delipidation pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MAU2, MT-CO3, and ATG4B_S383, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein delipidation activity versus MAU2 in GBM (Pearson r = 0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MAU2 →	+0.211	+0.573	<.001	.004	3	3
GBM	MT-CO3 →	-0.600	-0.994	<.001	<.001	3	3
UCEC	ATG4B_S383 →	+0.937	+0.353	<.001	<.001	3	3
OV	HNRNPA0_S280 →	+0.613	+0.637	.001	.001	3	3
PDAC	METTL15 →	+0.732	+0.767	.002	.003	3	3
UCEC	HOXD9 →	-1.372	-0.287	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051697 vs MAU2 — GBM

Explore this scatter interactively →