Protein delipidation

Across TCGA cell cohorts, RNA activity of the Protein delipidation pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF862, VMAC, and PMM1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF862 grouped by Protein delipidation-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	ZNF862 →	-1.394	-1.656	.004	<.001	3	6
BREAST	VMAC →	-0.735	-0.885	.005	.006	3	5
BLOOD_Leukemia	PMM1 →	-0.967	-1.234	.004	.006	3	4
BLOOD_Leukemia	SLC35F2 →	+1.241	+1.185	.002	<.001	3	4
BREAST	NEK8 →	-0.972	-0.820	<.001	.007	3	4
STOMACH	RAB4B →	-0.953	-1.275	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF862 by Protein delipidation activity — BONE

Explore this box plot interactively →