Pointed-end actin filament capping

Across TCGA patient cohorts, RNA activity of the Pointed-end actin filament capping pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SORBS1, TPM1, and TPM2, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pointed-end actin filament capping activity versus SORBS1 in COAD (Pearson r = 0.75).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	SORBS1 →	+0.847	+0.351	<.001	<.001	3	10
COAD	TPM1 →	+0.898	+0.375	<.001	<.001	3	10
COAD	TPM2 →	+1.178	+0.373	<.001	<.001	3	10
HNSC	NEXN_S226 →	+1.193	+0.832	<.001	<.001	3	10
COAD	RSU1 →	+0.508	+0.321	<.001	<.001	3	9
UCEC	SORBS3 →	+0.753	+0.337	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051694 vs SORBS1 — COAD

Explore this scatter interactively →