Establishment of Golgi localization

Across TCGA patient cohorts, RNA activity of the Establishment of Golgi localization pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are WDR4_S391, SLC9A3R1, and TUBB2B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Establishment of Golgi localization activity versus WDR4_S391 in LUAD (Pearson r = -0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	WDR4_S391 →	-0.387	-0.026	.001	<.001	3	5
BRCA	SLC9A3R1 →	-0.556	-0.044	<.001	<.001	3	5
BRCA	TUBB2B →	+0.938	+0.039	.004	.009	3	5
LSCC	COA6 →	-0.407	-0.049	.001	.003	3	5
BRCA	NES →	+0.481	+0.029	<.001	.003	3	5
LUAD	ZMYM4 →	+0.212	+0.029	.002	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051683 vs WDR4_S391 — LUAD

Explore this scatter interactively →