Establishment of Golgi localization

Across TCGA patient cohorts, RNA activity of the Establishment of Golgi localization pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARHGAP21, PRTFDC1, and LDLRAD4-AS1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Establishment of Golgi localization activity versus ARHGAP21 in GBM (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ARHGAP21 →	+0.380	+0.541	.005	.002	3	6
BRCA	PRTFDC1 →	+0.816	+0.102	.003	.005	3	3
OV	LDLRAD4-AS1 →	-0.065	-0.158	.008	.001	3	3
BRCA	RPS6P26 →	+0.610	+0.096	<.001	.005	3	3
GBM	IL1RL1 →	-0.423	-0.451	.002	.002	3	2
GBM	UTP25 →	-0.194	-0.419	.008	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051683 vs ARHGAP21 — GBM

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