Establishment of Golgi localization

Across TCGA cell cohorts, RNA activity of the Establishment of Golgi localization pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C2CD2L, ATP6V1A, and SQOR, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Establishment of Golgi localization activity versus C2CD2L in LUNG_NSCLC_LUSC (Pearson r = 0.76).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	C2CD2L →	+1.464	+0.285	.009	.003	3	6
LIVER	ATP6V1A →	+0.942	+0.191	.001	.003	3	5
OVARY	SQOR →	+2.407	+0.270	<.001	<.001	3	4
OESOPHAGUS	SCARA3 →	-2.650	-0.235	.001	.005	3	4
PANCREAS	KAT2A →	+0.740	+0.233	.004	.001	3	4
LUNG_NSCLC_LUSC	PUS3 →	+0.759	+0.234	.007	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051683 vs C2CD2L — LUNG_NSCLC_LUSC

Explore this scatter interactively →