Establishment of centrosome localization

Across TCGA patient cohorts, RNA activity of the Establishment of centrosome localization pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MISP, EZR, and CAPN9, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Establishment of centrosome localization activity versus MISP in BRCA (Pearson r = 0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MISP →	+1.569	+0.208	<.001	<.001	3	6
UCEC	EZR →	+0.810	+0.949	<.001	<.001	3	6
PDAC	CAPN9 →	+1.347	+0.679	.002	.001	3	5
HNSC	NCKAP1 →	+0.498	+0.826	.002	.002	3	4
LSCC	TSPAN1 →	+1.606	+0.371	<.001	.005	3	4
LSCC	GPRC5A →	+1.762	+0.527	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051660 vs MISP — BRCA

Explore this scatter interactively →