Maintenance of organelle location

Across TCGA patient cohorts, RNA activity of the Maintenance of organelle location pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLEKHG4B, TTI1, and PPIH, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Maintenance of organelle location activity versus PLEKHG4B in LUAD (Pearson r = -0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	PLEKHG4B →	-0.893	-0.146	<.001	.001	3	4
UCEC	TTI1 →	-0.377	-0.279	.003	.003	3	3
UCEC	PPIH →	-0.226	-0.258	.001	.002	3	3
GBM	SELENOW →	+0.486	+0.733	<.001	.001	3	3
LUAD	EIF2B2 →	-0.369	-0.205	.001	<.001	3	3
LSCC	PRSS12 →	+1.112	+0.298	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051657 vs PLEKHG4B — LUAD

Explore this scatter interactively →