Maintenance of organelle location

Across TCGA cell cohorts, RNA activity of the Maintenance of organelle location pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UVRAG, TBCCD1, and SIRT1, each associated with the pathway in up to 17 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Maintenance of organelle location activity versus UVRAG in LUNG_NSCLC_LUSC (Pearson r = 0.74).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	UVRAG →	+0.985	+0.117	<.001	<.001	3	17
LUNG_NSCLC_LUSC	TBCCD1 →	+0.996	+0.087	.008	.002	3	16
BLOOD_Lymphoma	SIRT1 →	+1.264	+0.079	<.001	<.001	3	14
BLOOD_Myeloma	FBXO45 →	+0.817	+0.060	<.001	.003	3	13
OVARY	CEP295 →	+0.942	+0.113	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	THAP12 →	+1.385	+0.077	.001	.003	2	13

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051657 vs UVRAG — LUNG_NSCLC_LUSC

Explore this scatter interactively →