Maintenance of organelle location

Across TCGA cell cohorts, RNA activity of the Maintenance of organelle location pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VAT1, MED4, and PNPLA8, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Maintenance of organelle location activity versus VAT1 in SKIN (Pearson r = -0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	VAT1 →	-1.309	-0.875	.004	.008	3	4
BLOOD_Leukemia	MED4 →	-0.527	-0.877	.002	<.001	3	4
OESOPHAGUS	PNPLA8 →	-1.173	-1.410	.006	<.001	3	4
LUNG_NSCLC_LUSC	CA5B →	-1.283	-1.851	.004	<.001	3	4
OVARY	VPS37A →	-1.046	-1.424	.001	.003	3	4
BONE	DIP2C →	-1.085	-1.324	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051657 vs VAT1 — SKIN

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