Maintenance of organelle location

Across TCGA cell cohorts, RNA activity of the Maintenance of organelle location pathway is significantly associated with the protein abundance of multiple proteins, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ATP6V1H, PSMD7, and NIP7, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Maintenance of organelle location activity versus ATP6V1H in BONE (Pearson r = -0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	ATP6V1H →	-0.756	-0.898	.003	.006	2	9
LIVER	PSMD7 →	-1.220	-1.625	.004	<.001	3	8
OESOPHAGUS	NIP7 →	+0.753	+0.840	.001	.006	3	8
BONE	SPOUT1 →	+0.972	+1.108	<.001	.001	2	8
OVARY	DCTN2 →	-1.372	-1.352	.004	.004	3	7
LIVER	PSMC4 →	-1.114	-1.715	.004	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051657 vs ATP6V1H — BONE

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