Establishment of mitochondrion localization

Across TCGA cell cohorts, RNA activity of the Establishment of mitochondrion localization pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SAP30, ABCE1, and TMEM209, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Establishment of mitochondrion localization activity versus SAP30 in BLOOD_Leukemia (Pearson r = -0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SAP30 →	-0.751	-0.578	.001	.002	3	6
LARGE_INTESTINE	ABCE1 →	-0.512	-0.357	.007	.004	3	5
LIVER	TMEM209 →	-0.501	-0.386	.006	.009	3	4
STOMACH	NABP2 →	-1.006	-0.317	<.001	.002	3	4
STOMACH	SERPINA1 →	+5.001	+0.295	.009	.001	3	4
BLOOD_Leukemia	KIN →	-0.621	-0.722	.006	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051654 vs SAP30 — BLOOD_Leukemia

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