Spindle localization

Across TCGA cell cohorts, RNA activity of the Spindle localization pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GLMP, SMTN, and WDR44, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Spindle localization activity versus GLMP in BLOOD_Leukemia (Pearson r = 0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GLMP →	+1.049	+0.109	.009	.007	3	6
STOMACH	SMTN →	+1.054	+0.324	.006	.008	3	5
BLOOD_Leukemia	WDR44 →	+0.531	+0.144	.009	.009	3	4
CNS	LRRFIP1 →	+0.684	+0.155	.001	.005	3	4
CNS	TPCN2 →	+0.644	+0.236	.007	.006	3	4
CNS	ANXA5 →	+0.831	+0.173	.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051653 vs GLMP — BLOOD_Leukemia

Explore this scatter interactively →