Maintenance of location in cell

Across TCGA cell cohorts, RNA activity of the Maintenance of location in cell pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UBA7, CMPK2, and PDCD11, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, UBA7 grouped by Maintenance of location in cell-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	UBA7 →	-1.654	-0.521	.002	.003	3	5
CNS	CMPK2 →	-1.018	-0.350	<.001	.006	3	4
PANCREAS	PDCD11 →	+0.666	+0.194	.002	.004	3	4
LUNG_NSCLC_LUSC	HLA-C →	-1.568	-0.259	.008	.002	3	4
LARGE_INTESTINE	TMEM222 →	-0.466	-0.203	.004	<.001	3	4
STOMACH	AP5Z1 →	-0.717	-0.225	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

UBA7 by Maintenance of location in cell activity — CNS

Explore this box plot interactively →