Maintenance of location in cell

Across TCGA cell cohorts, RNA activity of the Maintenance of location in cell pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYB, FRMD6, and MARS2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Maintenance of location in cell activity versus MYB in BREAST (Pearson r = -0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	MYB →	-2.251	-0.244	<.001	<.001	3	7
OVARY	FRMD6 →	+2.015	+0.234	.008	<.001	3	7
STOMACH	MARS2 →	-0.687	-0.187	.003	.006	2	7
PANCREAS	S100A2 →	+3.517	+0.222	<.001	<.001	3	6
OVARY	CAV1 →	+2.457	+0.190	.003	.006	2	7
LUNG_NSCLC_LUAD	VPS45 →	-0.895	-0.218	.002	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051651 vs MYB — BREAST

Explore this scatter interactively →