Vesicle localization

Across TCGA patient cohorts, RNA activity of the Vesicle localization pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are THRAP3_S55, MRPS26, and RPS3A, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vesicle localization activity versus THRAP3_S55 in OV (Pearson r = -0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	THRAP3_S55 →	-0.734	-0.036	<.001	<.001	3	6
OV	MRPS26 →	-0.350	-0.027	<.001	.005	3	6
GBM	RPS3A →	-0.182	-0.040	.002	<.001	3	6
GBM	RPL10A →	-0.173	-0.034	<.001	<.001	3	5
HNSC	RPL30 →	-0.201	-0.042	.005	.002	3	5
BRCA	RPL4 →	-0.296	-0.013	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051648 vs THRAP3_S55 — OV

Explore this scatter interactively →