Vesicle localization

Across TCGA cell cohorts, RNA activity of the Vesicle localization pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NEK8, PHF23, and SRP9, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NEK8 grouped by Vesicle localization-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	NEK8 →	-1.187	-0.195	<.001	.006	3	4
BLOOD_Myeloma	PHF23 →	-0.897	-0.136	.001	.007	3	4
LUNG_NSCLC_LUSC	SRP9 →	+0.916	+0.191	.001	.007	3	4
BLOOD_Lymphoma	HDAC3 →	-0.469	-0.131	.003	.001	3	4
BLOOD_Myeloma	CDK19 →	+1.297	+0.200	.004	.008	3	3
BLOOD_Myeloma	ZNF511 →	-1.475	-0.192	.004	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NEK8 by Vesicle localization activity — BLOOD_Myeloma

Explore this box plot interactively →