Vesicle localization

Across TCGA cell cohorts, RNA activity of the Vesicle localization pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GARRE1, KIAA0232, and BSDC1, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vesicle localization activity versus GARRE1 in STOMACH (Pearson r = 0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	GARRE1 →	+1.250	+0.045	.007	.004	3	14
BLOOD_Myeloma	KIAA0232 →	+1.300	+0.042	<.001	<.001	3	14
BLOOD_Lymphoma	BSDC1 →	+0.860	+0.037	<.001	<.001	3	14
BREAST	ACOX1 →	+0.977	+0.044	.003	.003	3	13
STOMACH	HECTD4 →	+1.112	+0.053	.001	.002	3	13
STOMACH	MTHFR →	+1.068	+0.044	.002	.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051648 vs GARRE1 — STOMACH

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