Vesicle localization

Across TCGA cell cohorts, RNA activity of the Vesicle localization pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LEMD2, LIAS, and DYSF, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vesicle localization activity versus LEMD2 in KIDNEY (Pearson r = 0.78).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	LEMD2 →	+0.864	+0.260	<.001	<.001	3	3
KIDNEY	LIAS →	-0.783	-0.167	.009	.007	2	4
URINARY_TRACT	DYSF →	+3.607	+0.274	.001	.008	3	3
PANCREAS	ZFPL1 →	+0.564	+0.159	.001	.002	3	3
PANCREAS	TMEM71 →	+1.471	+0.162	.002	.001	3	3
LIVER	MCOLN2 →	-1.930	-0.247	.006	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051648 vs LEMD2 — KIDNEY

Explore this scatter interactively →