Golgi localization

Across TCGA patient cohorts, RNA activity of the Golgi localization pathway is significantly associated with the RNA expression of multiple genes, with the THYM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNMT, MIB1, and XIAP, each associated with the pathway in up to 34 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Golgi localization activity versus RNMT in THYM (Pearson r = 0.79).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THYM	RNMT →	+0.947	+0.077	<.001	<.001	3	34
UVM	MIB1 →	+1.235	+0.035	<.001	<.001	3	34
UVM	XIAP →	+1.152	+0.035	<.001	<.001	3	34
THYM	RBL2 →	+1.532	+0.082	<.001	<.001	3	34
KIRP	SETX →	+0.947	+0.058	<.001	<.001	3	34
KICH	CCSER2 →	+1.150	+0.036	<.001	<.001	3	34

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051645 vs RNMT — THYM

Explore this scatter interactively →