Golgi localization

Across TCGA cell cohorts, RNA activity of the Golgi localization pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COPG1, CDC42, and CACNA1D, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, COPG1 grouped by Golgi localization-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	COPG1 →	-0.597	-0.409	<.001	<.001	3	5
BLOOD_Leukemia	CDC42 →	-0.281	-0.331	<.001	.007	3	4
BONE	CACNA1D →	+0.215	+0.285	.005	.008	3	4
SKIN	GPR171 →	+0.235	+0.297	.001	<.001	3	4
BLOOD_Myeloma	POLD3 →	+0.336	+0.472	.004	.002	3	4
BREAST	COG1 →	-0.324	-0.315	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

COPG1 by Golgi localization activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →