Golgi localization

Across TCGA cell cohorts, RNA activity of the Golgi localization pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DDX6, TALDO1, and SLC25A42, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DDX6 grouped by Golgi localization-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	DDX6 →	-0.590	-0.435	.007	.007	3	4
STOMACH	TALDO1 →	+0.834	+0.267	.003	.007	3	3
STOMACH	SLC25A42 →	-1.021	-0.383	.004	.004	3	3
BLOOD_Lymphoma	CTDNEP1 →	+0.980	+0.678	.003	.003	3	3
KIDNEY	PRR22 →	+0.619	+0.186	.007	.005	3	3
LIVER	SSR3 →	+0.753	+0.337	.009	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DDX6 by Golgi localization activity — BLOOD_Leukemia

Explore this box plot interactively →