Endoplasmic reticulum localization

Across TCGA patient cohorts, RNA activity of the Endoplasmic reticulum localization pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FGD3_S547, TLN1_S2338, and GNAI2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endoplasmic reticulum localization activity versus FGD3_S547 in LSCC (Pearson r = -0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	FGD3_S547 →	-0.279	-0.034	.008	<.001	3	5
LUAD	TLN1_S2338 →	-0.457	-0.049	<.001	.005	3	5
LSCC	GNAI2 →	-0.218	-0.044	.001	<.001	3	5
COAD	LXN →	-0.292	-0.038	.002	<.001	3	5
HNSC	FNBP1 →	-0.376	-0.062	<.001	.002	3	5
BRCA	ANXA9 →	+0.674	+0.033	.002	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051643 vs FGD3_S547 — LSCC

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