Endoplasmic reticulum localization

Across TCGA patient cohorts, RNA activity of the Endoplasmic reticulum localization pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF681, MTO1, and CCDC144CP, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endoplasmic reticulum localization activity versus ZNF681 in OV (Pearson r = -0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ZNF681 →	-0.561	-0.171	<.001	<.001	3	4
CCRCC	MTO1 →	-0.175	-0.175	.005	<.001	3	4
PDAC	CCDC144CP →	-0.284	-0.736	.001	.006	3	3
LUAD	MIR4671 →	+0.689	+0.381	.001	.001	3	3
GBM	RNU6-973P →	+0.297	+0.261	.001	.004	3	3
PDAC	UBE2V2P2 →	-0.366	-0.717	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051643 vs ZNF681 — OV

Explore this scatter interactively →