Endoplasmic reticulum localization

Across TCGA cell cohorts, RNA activity of the Endoplasmic reticulum localization pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HMBS, HPSE, and SMCO1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, HMBS grouped by Endoplasmic reticulum localization-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	HMBS →	-0.731	-1.113	.009	.002	3	4
URINARY_TRACT	HPSE →	+2.211	+1.939	<.001	<.001	3	4
URINARY_TRACT	SMCO1 →	-0.072	-2.180	.002	<.001	3	4
SKIN	LRP5L →	+0.474	+0.784	<.001	.003	3	4
LARGE_INTESTINE	NFS1 →	-0.654	-0.921	<.001	<.001	3	4
PANCREAS	ALDH5A1 →	-1.163	-1.586	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HMBS by Endoplasmic reticulum localization activity — BLOOD_Myeloma

Explore this box plot interactively →