Endoplasmic reticulum localization

Across TCGA cell cohorts, RNA activity of the Endoplasmic reticulum localization pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ESYT2, SPAG1, and S100A10, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endoplasmic reticulum localization activity versus ESYT2 in SKIN (Pearson r = 0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ESYT2 →	+1.416	+0.287	<.001	<.001	3	9
BONE	SPAG1 →	+1.609	+0.222	<.001	.002	3	7
OVARY	S100A10 →	+2.557	+0.279	.002	<.001	2	8
LUNG_SCLC	TMBIM6 →	+0.989	+0.229	<.001	<.001	3	7
OVARY	TANC1 →	+0.759	+0.168	.004	.002	3	6
BONE	EEF2 →	-1.093	-0.258	.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051643 vs ESYT2 — SKIN

Explore this scatter interactively →